16589 Edwards Shop Rd, Remington, VA | Get?Directions??
$5.00
Demonstrations, presentations, trade show, etc.
Kelly's Ford Equestrian Center
Details here: http://www.piedmonthorseexpo.com/
38.47171
-77.78439
primary
April 6, 2013, 10:00 am?3:00 pm
16589 Edwards Shop Rd, Remington, VA
/events/piedmont-horse-expo
/locations/9179462
Source: http://manassas.patch.com/events/piedmont-horse-expo
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Public release date: 4-Apr-2013
Share ] Contact: Nancy Ambrosiano
nwa@lanl.gov
505-667-0471
DOE/Los Alamos National Laboratory
LOS ALAMOS, N.M., April 4, 2013Observing the evolution of a particular type of antibody in an infected HIV-1 patient, a study spearheaded by Duke University, including analysis from Los Alamos National Laboratory, has provided insights that will enable vaccination strategies that mimic the actual antibody development within the body.
The kind of antibody studied is called a broadly cross-reactive neutralizing antibody, and details of its generation could provide a blueprint for effective vaccination, according to the study's authors. In a paper published online in Nature this week, the team reported on the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection.
The observations trace the co-evolution of the virus and antibodies, ultimately leading to the development of a strain of the potent antibodies in this subject, and they could provide insights into strategies to elicit similar antibodies by vaccination.
Patients early in HIV-1 infection have primarily a single "founder" form of the virus that has been strong enough to infect the patient, even though the population in the originating patient is usually far more diverse and contains a wide variety of HIV mutations. Once the founder virus is involved in the new patient's system, the surrounding environment stimulates the HIV to mutate and form a unique, tailored population of virus that is specific to the individual.
The team, including Bette Korber, Peter Hraber, and S. Gnanakaran, of Los Alamos National Laboratory, led by Barton Haynes of Duke University School of Medicine in Durham, North Carolina, with colleagues at Boston University, the National Institutes of Health, and other institutions as part of a large collaboration, showed that broadly neutralizing antibodies developed only after the population of viruses in the individual had matured and become more diverse.
"Our hope is that a vaccine based on the series of HIV variants that evolved within this subject, that were together capable of stimulating this potent broad antibody response in his natural infection, may enable triggering similar protective antibody responses in vaccines," said Bette Korber, leader of the Los Alamos team.
###
The research, "Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus," is at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12053.html online.
This study was supported by the National Institutes of Allergy and Infectious Diseases (NIAID) and by intramural National Institutes of Health (NIH) support for the NIAID Vaccine Research Center, by grants from the NIH, NIAID, AI067854 (the Center for HIV/AIDS Vaccine Immunology) and AI100645 (the Center for Vaccine Immunology-Immunogen Discovery). Use of sector 22 (Southeast Region Collaborative Access team) at the Advanced Photon Source at Argonne National Laboratory was supported by the US Department of Energy, Basic Energy Sciences, Office of Science, under contract number W-31-109-Eng-38.
About Los Alamos National Laboratory
Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is operated by Los Alamos National Security, LLC, a team composed of Bechtel National, the University of California, The Babcock & Wilcox Company and URS for the Department of Energy's National Nuclear Security Administration.
Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health and global security concerns.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 4-Apr-2013 Share ] Contact: Nancy Ambrosiano
nwa@lanl.gov
505-667-0471
DOE/Los Alamos National Laboratory
LOS ALAMOS, N.M., April 4, 2013Observing the evolution of a particular type of antibody in an infected HIV-1 patient, a study spearheaded by Duke University, including analysis from Los Alamos National Laboratory, has provided insights that will enable vaccination strategies that mimic the actual antibody development within the body.
The kind of antibody studied is called a broadly cross-reactive neutralizing antibody, and details of its generation could provide a blueprint for effective vaccination, according to the study's authors. In a paper published online in Nature this week, the team reported on the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection.
The observations trace the co-evolution of the virus and antibodies, ultimately leading to the development of a strain of the potent antibodies in this subject, and they could provide insights into strategies to elicit similar antibodies by vaccination.
Patients early in HIV-1 infection have primarily a single "founder" form of the virus that has been strong enough to infect the patient, even though the population in the originating patient is usually far more diverse and contains a wide variety of HIV mutations. Once the founder virus is involved in the new patient's system, the surrounding environment stimulates the HIV to mutate and form a unique, tailored population of virus that is specific to the individual.
The team, including Bette Korber, Peter Hraber, and S. Gnanakaran, of Los Alamos National Laboratory, led by Barton Haynes of Duke University School of Medicine in Durham, North Carolina, with colleagues at Boston University, the National Institutes of Health, and other institutions as part of a large collaboration, showed that broadly neutralizing antibodies developed only after the population of viruses in the individual had matured and become more diverse.
"Our hope is that a vaccine based on the series of HIV variants that evolved within this subject, that were together capable of stimulating this potent broad antibody response in his natural infection, may enable triggering similar protective antibody responses in vaccines," said Bette Korber, leader of the Los Alamos team.
###
The research, "Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus," is at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12053.html online.
This study was supported by the National Institutes of Allergy and Infectious Diseases (NIAID) and by intramural National Institutes of Health (NIH) support for the NIAID Vaccine Research Center, by grants from the NIH, NIAID, AI067854 (the Center for HIV/AIDS Vaccine Immunology) and AI100645 (the Center for Vaccine Immunology-Immunogen Discovery). Use of sector 22 (Southeast Region Collaborative Access team) at the Advanced Photon Source at Argonne National Laboratory was supported by the US Department of Energy, Basic Energy Sciences, Office of Science, under contract number W-31-109-Eng-38.
About Los Alamos National Laboratory
Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is operated by Los Alamos National Security, LLC, a team composed of Bechtel National, the University of California, The Babcock & Wilcox Company and URS for the Department of Energy's National Nuclear Security Administration.
Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health and global security concerns.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/danl-aec040413.php
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Discover Video today announced DEVOS 3.0, a new media management and video streaming system for private and public enterprises. DEVOS 3.0 breaks the barrier in price, features, and flexibility for a complete hybrid video distribution system that can be used inside the firewall and on the public Internet simultaneously.?? Not only does it manage and deliver live and on-demand video and multimedia, but it also includes digital signage, a unique video priority alert system, Roku integration, and more.
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?DEVOS 3.0 is perfect for enterprises that need to distribute live and on-demand media efficiently and securely to employees, students, partners, and customers?, said Rich Mavrogeanes, president and CEO of Discover Video. ?In our modern mixed desktop-and-mobile world, DEVOS 3.0 combines the best features of web services like YouTube with world-class live streaming, any-platform delivery, set top boxes, Digital Signage, ?and Priority Alert.?
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DEVOS 3.0 key features include:?
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For schools, businesses, and government the DEVOS 3.0 system provides a private portal with the ability to customize viewing pages and content, while providing detailed statistics.?? It can be purchased as both an on premises server or Cloud service.? For larger organizations a hybrid approach permits fine tuning live and on-demand video distribution, eliminating any network bottlenecks.
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A bonus for schools and universities is the Priority Alert feature, extensively used by the U.S. military.? Within seconds, a live or recorded video message can be sent to thousands of network connected computers without end user action, notifying them of impending emergencies, storms or major announcements.? ?The DEVOS 3.0 Digital Signage feature, which displays HD quality live or recording video, text, or web pages on large monitors, is also integrated with Priority Alert.
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DEVOS is the first private video system to incorporate the popular, inexpensive Roku set top box into the proposition. The entire live and on-demand video library can be viewed on a under $100 box, making it extremely easy to deploy video everywhere. ???
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The DEVOS applications include distance learning/lecture capture at colleges and universities, flipping the classroom or morning announcements in K-12 schools, video training and executive broadcasts in businesses, and government meeting distribution in towns, cities, states, and federal agencies.? It can also be used to delivery live video feeds from security IP cameras located anywhere.
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Apr. 3, 2013 ? Ad?lie penguins may actually benefit from warmer global temperatures, the opposite of other polar species, according to a breakthrough study by an international team led by University of Minnesota Polar Geospatial Center researchers. The study provides key information affirming hypothetical projections about the continuing impact of environmental change.
Researchers from the United States and New Zealand used a mix of old and new technology studying a combination of aerial photography beginning in 1958 and modern satellite imagery from the 2000s. They found that the population size of an Ad?lie penguin colony on Antarctica's Beaufort Island near the southern Ross Sea increased 84 percent (from 35,000 breeding pairs to 64,000 breeding pairs) as the ice fields retreated between 1958-2010, with the biggest change in the last three decades. The average summer temperature in that area increased about a half a degree Celsius per decade since the mid-1980s.
The first-of-its-kind study was published today in PLOS ONE, a leading peer-reviewed scientific journal. The research affirms models published in 2010 projecting how south polar penguins will respond to changed habitat as Earth's atmosphere reaches 2 degrees Celsius above pre-industrial levels, a point that is rapidly approaching.
The study showed that available habitat for Ad?lie penguins on the main portion of the Beaufort colony, on the south coast, increased 71 percent since 1958, with a 20 percent increase from 1983-2010. The extent of the snow and ice field to the north of the main colony did not change from 1958-1983, but then retreated 543 meters from 1983-2010.
In addition to the overall population growth, researchers saw an increase in population density within the colony as it filled in what used to be unsuitable habitat covered in snow and ice. They also found that the emigration rates of birds banded as chicks on Beaufort Island to colonies on nearby Ross Island decreased after 2005 as available habitat on Beaufort increased, leading to altered dynamics of the population studied.
"This research raises new questions about how Antarctic species are impacted by a changing environment," said Michelle LaRue, the paper's co-author and research fellow at the Polar Geospatial Center in the University of Minnesota's College of Science and Engineering. "This paper encourages all of us to take a second look at what we're seeing and find out if this type of habitat expansion is happening elsewhere to other populations of Ad?lie penguins or other species."
Penguin expert and study co-author David Ainley, a lead author of an earlier study, agreed that this study gives researchers important new information.
"We learned in previous research from 2001-2005 that it is a myth that penguins never move to a new colony in large numbers. When conditions are tough, they do," said Ainley, a senior marine wildlife ecologist with H.T. Harvey and Associates, an environmental consulting company in California. "This study at Beaufort and Ross Islands provides empirical evidence about how this penguin attribute will contribute to their response to climate change."
Ad?lie penguins are common along the southern Antarctic coast. They are smaller than their Emperor penguin counterparts standing about 46 to 75 cm (18 to 30 inches) when upright and weighing about 4.5-5.4 kg (10-12 pounds). The Ad?lie penguin lives only where there is sea ice but needs the ice-free land to breed. Breeding pairs produce on average one chick per year and return to the same area to breed if conditions haven't changed.
To determine changes in available nesting habitat in this study, researchers gathered aerial photos during the penguin incubation period in 1958, 1983 and 1993 and high-resolution satellite images from 2005 and 2010. Researchers overlaid the images exactly, lining up rocks and other geographical landmarks. They studied guano (penguin feces and urine) stains to determine the available habitat.
In the future, researchers plan to use additional satellite imagery to look at other Ad?lie penguin populations to help understand the dynamics and environmental factors that influence regional populations.
"This study brought together researchers from different academic disciplines who all contributed their expertise," LaRue said. "We had people who study climate change, spatial analysis, and wildlife population dynamics. This is how good science leads to results."
In addition to LaRue and Ainley, other researchers involved in the study included Matt Swanson, a graduate student researcher at the University of Minnesota Polar Geospatial Center; Katie M. Dugger from Oregon State University; Phil O'B. Lyver from Landcare Research in New Zealand; Kerry Barton from Bartonk Solutions in New Zealand; and Grant Ballard from PRBO Conservation Science in California.
The study was primarily funded by the National Science Foundation (NSF).
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The above story is reprinted from materials provided by University of Minnesota.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/VISdTbqa9Ms/130404092827.htm
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Some Firefox releases have more noticeable changes than others. We'd say that the newly finalized Firefox 20 is firmly in that first camp. The new release gives desktop users a Safari-like download manager that pops out from the toolbar, making it possible to check on a big download without anything so ungainly as a separate window. Also new are more refined approaches to private browsing that can open a new window (on the desktop) or tab (on Android) for those extra-personal, secretive... gift-shopping sessions, according to Mozilla. Whether or not you believe that euphemism, there's no doubt that Android users receive their own specific treat through support for lower-end ARMv6 phones, including relative oldies like the HTC Legend and Samsung Galaxy Q. Hit the source links to stay current with Firefox, no matter how innocuous your intentions might be.
Filed under: Internet, Software
Via: Mozilla Blog
Source: Mozilla, Google Play
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Apr. 1, 2013 ? When companies put a human face on their brand, the public usually responds positively. This advertising approach has brought us alarm clocks with sleepy faces and color-coated chocolate candies with legs and arms.
But a new study, published online ahead of print in the Journal of Marketing, finds there is a greater backlash by the public when a product branded with human characteristics fails.
Lead author Marina Puzakova, an assistant professor of marketing at Oregon State University, said even though consumers can tell a camera designed with human characteristics such as little eyes and legs isn't a person, the very act of humanizing a product can be a powerful tool.
"Somehow, now the product seems alive and mindful, and therefore can be perceived as having intentions and its own motivations to act in a certain way," Puzakova said. "This perception of intentions can be extremely strong -- consumers now see the brand as performing bad intentionally and therefore consumers develop more negative sentiments toward the brand."
Puzakova conducted five experiments with products that had experienced negative publicity. As a general procedure, participants saw advertisements of both existing and fictitious products, where "human" characteristics, such as arms, legs, or facial-like features were manipulated. Then Puzakova showed participants news reports about how the product had failed in some way, not lived up to its advertising claim, or did not function based on consumer expectations.
In every instance, participants reported that they had stronger negative reactions to the products that were given human characteristics, also known as "brand anthropomorphization."
"Brand anthropomorphization can be a very powerful advertising tool, so I am definitely not saying that companies shouldn't use it," Puzakova said. "However, they need to be aware that when they imbue their products with human-like characteristics, any backlash when something goes wrong could be stronger."
Puzakova's study found that the strength of negative reactions depended on consumer personality differences as well. Based on a personality test she gave participants, she found that people who believe in "personality stability," or that personality traits are always the same and don't change over time, tended to have stronger negative feelings towards anthropomorphized brands.
"Broadly speaking, men tend to believe in personality stability more than women, and seniors as well," Puzakova said. "Also, some cultures tend to believe in this more than others. This can be important for advertisers to know, depending on who their target market is.
Having a deeper knowledge about their target markets, companies can also design their advertising communications tailored for different types of consumers. For example, marketers may want to emphasize flexibility and change in an ad campaign in order to reverse negative attitudes by male consumers, who tend to believe in personality stability.
Puzakova's research also has a lesson for companies whose brands fail because of a product malfunction.
"As consumers who believe in stability of personality traits react to product failures more negatively, our research finds that companies need to provide either monetary compensation or give away coupons," Puzakova said. "Offering a public apology is not enough. For instance, companies that have a humanized brand marketed heavily towards seniors may need to be prepared to generously compensate those consumers if something goes wrong."
The bottom line, Puzakova said, is companies need to know their audience and the possible dangers of humanizing a brand when a product malfunctions. It can be a powerful advertising tool, but if the product fails in some way, the damage control could be costly and timely.
Hyokjin Kwak of Drexel University and Joseph Rocereto of Monmouth University contributed to this study.
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The above story is reprinted from materials provided by Oregon State University.
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Journal Reference:
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
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Conservation biologist Kent Redford talks about the issues facing the intersection of synthetic biology and conservation biology and a conference that starts April 9th called "How will synthetic biology and conservation shape the future of nature?"
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Conservation biologist Kent Redford, recently of the Wildlife Conservation Society and now with Archipelago Consulting, talks about the issues facing the intersection of synthetic biology and conservation biology. He organized a conference that starts April 9th at Clare College in Cambridge, England, called ?How will synthetic biology and conservation shape the future of nature??
Redford is a co-author of a paper in the journal PLoS Biology [Kent H. Redford, William Adams and Georgina M. Mace, Synthetic Biology and Conservation of Nature: Wicked Problems and Wicked Solutions] that frames the issues the conference will begin to address.
Source: http://rss.sciam.com/click.phdo?i=f47ce042a35b59695d69f1f1a5ad839c
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